MK-677 (Ibutamoren) is a growth hormone secretagogue, which mimics the growth hormone. It also increases insulin-like growth factor 1 (IGF-1). Researchers have found MK-677 to help build muscle, reduce muscle wasting, increase bone density, and reverse aging. •Other Name(s): Ibutamoren Mesylate, MK-0677, L-163,191, L163191, Nutrobal, Oratrope, Crescendo •CAS: 159752-10-0 •Powder Purity: >99% HPLC •Solubility: Water, DMSO, Ethanol, Propylene Glycol •Molar Mass: 624.77 g/mol •Chemical Formula: C27H36N4O5S •Short term storage (weeks): 0-4 °C under dry condition •Long Term Storage (months): -20 °C under dry condition •Shelf Life: At least 4 years if properly stored •Melting Point: 156 – 158 °C •Appearance: Off-white to beige fine powder, hygroscopic, acrid odor, acrid metallic taste •Biological half-life: 24 hours •Suggested Intake: 25-50mgs/day

MK-677 (Ibutamoren) is a growth hormone secretagogue, which mimics the growth hormone. It also increases insulin-like growth factor 1 (IGF-1). Researchers have found MK-677 to help build muscle, reduce muscle wasting, increase bone density, and reverse aging.

Growth hormone pulse intensity can be increased through 4 possible mechanisms: 1.Increasing GHRH (growth hormone releasing hormone) release. 2.Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland. 3.Reducing somatostatin release (somatostatin turns off GH release). 4.Inhibiting of somatostatin receptor signaling.Mk-677 was found to work through all 4 of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.