• CUT YOUR RISK WITH PERQUE D3 CELL GUARD
  PERQUE D3 Cell Guard provides Vitamin D3 in a liquid form for
  optimum uptake and absorption.* Studies show Vitamin D3 may be
  the answer to many of our health issues today and in the future.
  THE SUNSHINE VITAMIN
  Vitamin D3 is the only vitamin our bodies can make with sun exposure
  by using the energy of UVB to convert 7-dehydrocholesterol into
  Vitamin D3. A largely held opinion is that it is technically not a vitamin
  but a hormone. The fear of skin cancer and just being in sun-starved
  latitudes prevents many individuals from obtaining the benefits of
  sunlight, and we are today a society of millions deficient in this valuable
  nutrient. Furthermore, as we age, we are less equipped to produce
  sufficient quantities of this vital nutrient.
  Good dietary sources of Vitamin D include fatty fish, like tuna, mackerel,
  and salmon, eggs and dairy. However, most Americans do not eat
  enough fish to get a healthy dose of Vitamin D, and fortified foods
  like milk and cereal simply do not provide enough of this important
  vitamin. Therefore, Vitamin D supplementation by far seems to be
  the best option.
  HOW MUCH IS REQUIRED?
  From a conservative 10 mcg (400 IU)/day as being the required intake
  to prevent rickets and osteomalacia, researchers now believe that
  these amounts are simply not enough. A typical dose for children is
  now 10-25 mcg (400-1000 IU)/day, and for healthy adults, amounts
  of 50-125 mcg (2000-5000 IU)/day are more realistic. The biochemical
  parameter used to gauge the Vitamin D status of an individual is the
  blood concentration of 25-hydroxyvitamin D [25(OH)D], which is the
  circulating Vitamin D metabolite calcidiol. Healthy blood levels of this
  metabolite range between 50-80 ng/ml. It is estimated that one billon
  people worldwide have deficiency or insufficiency, and up to half of
  U.S. adults and 30 percent of children and teenagers have Vitamin
  D deficiency, which is defined as a 25(OH)D level of<20ng/ml. Of
  the various forms of Vitamin D available, it is important to note that
  Vitamin D3 is most effective in increasing the blood levels of 25(OH)
  D.
  PERQUE D3 Cell Guard provides this safe and natural form of
  Vitamin D3 in a liquid form with Medium Chain Triglycerides
  (MCT) for effective uptake and absorption.* Additional protection
  to the D3 is provided by mixed natural tocopherols and ascorbyl
  palmitate in a natural rosemary extract.
  VITAMIN D3 FOR BONE HEALTH
  Vitamin D deficiency causes osteopenia, osteoporosis, and
  osteomalacia, increasing the risk of fracture, which indicates
  that Vitamin D3 sufficiency is essential for maximizing bone
  health. Vitamin D enhances intestinal absorption of calcium and
  phosphorus. Use PERQUE Bone Guard Forté to obtain adequate
  bone support nutrition. Vitamin D deficiency causes muscle
  weakness, increasing the risk of falls and fractures, which can be
  corrected with adequate Vitamin D3 supplementation.
  VITAMIN D3 AFFECTS THE IMMUNE SYSTEM
  Most organs and immune cells have a Vitamin D receptor, and
  some also have the capacity to metabolize 25-hydroxyvitamin
  D to the active form of Vitamin D: 1,25-dihydroxyvitamin D.
  1,25-dihydroxyvitamin D is a potent immunomodulator that is
  responsible for the downregulation of Th1 and upregulation of Th2
  cells. Rather than a simple downregulation of immune response,
  it blunts generalized over-proliferation of both lymphocytes and

monocytes while sharpening the immune system’s attack on specific targets. 1,25-dihydroxyvitamin D also inhibits the development of autoimmune
diseases like multiple sclerosis and irritable bowel syndrome and enhances the production and secretion of several hormones, including insulin.

VITAMIN D3 AND THE DIABETES CARDIOVASCULAR CONNECTION
Vitamin D deficiency has been associated with increased risk of type 1 diabetes
in children by affecting beta-cell function. Since Vitamin D deficiency also alters
hormone levels including insulin, this can increase the risk of diabetes, a major
contributor to cardiovascular disease (CVD). Glycemic control and insulin resistance
are also improved when Vitamin D deficiency is corrected. Low Vitamin D levels,
especially below 30 ng/ml, activate the renin-angiostensin-aldosterone system and
can lead to hypertension as well as stiffening and thickening of the heart and blood
vessels. As a result, the risk of heart attacks is increased.
VITAMIN D3 IMPROVES COGNITIVE HEALTH AND DECREASES STROKE
RISK*
Short-term and smaller clinical studies have indicated that serum 25(OH)D
concentration may be associated with dementia and cognitive function. Recent
results from a large clinical study involving 1,766 adults aged 65 years and older show
that those with normal cognitive function had higher levels of serum Vitamin D3 than
those who were cognitively impaired, further strengthening the neuroprotective
role of Vitamin D3. Research also indicates that Vitamin D levels can predict risk of
fatal stroke, and supplementation could even prevent stroke. Risk of stroke usually
increases with age, and since very low Vitamin D levels are common in the elderly,
this is an important connection.
VITAMIN D3 FOR OVERALL PROTECTION
Vitamin D deficiency is associated with obesity, hypertension, glucose intolerance,
monocytes while sharpening the immune system’s attack on specific targets. 1,25-dihydroxyvitamin D also inhibits the development of autoimmune
diseases like multiple sclerosis and irritable bowel syndrome and enhances the production and secretion of several hormones, including insulin.
and metabolic syndrome (insulin resistance). It has also been associated with other chronic illnesses including fibromyalgia, chronic fatigue,
colon and prostate health, autoimmune disorders, inflammation and repair and polycystic ovarian disease. Research about its connection with
other conditions is ongoing. In essence, Vitamin D3 provides valuable and complete health support. Consider PERQUE D3 Cell Guard for your
overall health protection and insurance.*
REFERENCES
1. Holick MF. Optimal Vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging 2007; 24(12):1017-29.
2. Holick MF. Diabetes and the Vitamin D connection. Curr Diab Rep 2008 Oct;8(5):393-8.
3. Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: A systematic review and meta-analysis. Arch Dis Child 2008
Jun; 93(6): 512-7.
4. Cantorna MT, Zhu Y, Froicu M, Wittke A.Vitamin D status, 1,25-dihydroxyVitamin D3, and the immune system. Am J Clin Nutr 2004 Dec; 80 (6): 1717S-1720S.
5. Massey P. Vitamin D supplements may stave off a stroke. Daily Herald Columnist 2008 Nov 4.
6. Llewellyn DJ, Langa K, Lang I. Serum 25- HydroxyVitamin D Concentration and Cognitive Impairment. J Geriatr Psychiatry Neurol 2008 Dec 10 (EPub).